What is a common side effect associated with oral retinoids?

Oral retinoids, such as isotretinoin, are well-known for their effectiveness in treating severe acne, but they come with a range of side effects due to their potent action on skin cell turnover. One of the most common and notable side effects is dry skin and mucous membranes. This occurs because retinoids significantly alter the process of keratinization and reduce sebaceous gland activity, leading to diminished oil production. As a result, patients often experience dryness not only of the skin but also in mucous membranes, which can affect areas like the lips, eyes, and nostrils. This drying effect is typically what leads patients to emphasize hydration strategies while on this treatment.

While increased sensitivity can indeed be a side effect of oral retinoids, the predominant and most frequently reported issue by patients tends to be dryness. Itchy eyes can occur due to dryness, but it isn't as universally experienced as skin and mucous membrane dryness. Excessive oil production is counterindicative of the effects of retinoids, as they actually aim to decrease oil production. Therefore, the association of dry skin and mucous membranes as a common side effect is well-founded and well-documented in clinical practice.